Document Detail

Alteration of reactivity of native arteries induced by venous graft placement.
MedLine Citation:
PMID:  8418986     Owner:  NLM     Status:  MEDLINE    
Occlusion of aortocoronary venous grafts can be due to thrombosis, atherosclerosis, or vasospasm. Investigations have focused on properties of the graft itself, and little is known about the vascular reactivity and function of the native arteries proximal and distal to the vein graft, although spasm of the native artery distal to the graft site has been observed in patients. We hypothesized that the function of the endothelium of the native arteries may be altered after surgery. Autogenous venous grafts were placed in femoral arteries of rabbits to study the reactivity of the native arteries after grafting. Four weeks after graft implantation, the vein graft, ipsilateral vein, and native artery proximal and distal to the graft were removed for in vitro studies. Morphological evaluation by scanning electron microscopy and fluorescence microscopy after labeling with acetylated low density lipoprotein labeled with 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate indicated the presence of an intact, metabolically active endothelial layer. There was no alteration in the contractile responses to phenylephrine of the arteries, vein grafts, or veins. Precontracted vein grafts, veins, and arterial segments proximal to the grafts relaxed when exposed to endothelium-dependent vasodilators (acetylcholine, arachidonic acid, and substance P), but the native arteries distal to the grafts did not. In bioassay cascade experiments, the distal artery did not release any measurable relaxing factor when exposed to acetylcholine. We conclude that the endothelium of the distal artery did not function normally. The extent and reversibility of altered endothelial function remain to be determined. This observation may help to explain the occurrence of myocardial infarction after aortocoronary bypass grafting in some patients.
D E Bjorling; R Saban; M W Tengowski; S M Gruel; V K Rao
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  72     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  319-29     Citation Subset:  IM    
Department of Surgical Sciences, School of Veterinary Medicine, Madison, WI 53706.
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MeSH Terms
Arachidonic Acid / pharmacology
Arteries / drug effects,  metabolism,  physiology*
Indomethacin / pharmacology
Microscopy, Electron, Scanning
Nitric Oxide / biosynthesis
Phenylephrine / pharmacology
Time Factors
Veins / drug effects,  transplantation*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 59-42-7/Phenylephrine

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