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Alteration of purinergic neurotransmission in atria isolated of streptozotocin-induced diabetic rats.
MedLine Citation:
PMID:  21983745     Owner:  NLM     Status:  Publisher    
ABSTRACT:: Cardiac dysfunctions are described in diabetes. However, the role of purinergic neurotransmission in diabetes-related cardiovascular diseases is unknown. The purpose of this study was to evaluate the purinergic neurotransmission in isolated atria from Streptozotocin-induced diabetic rats. The animals were grouped as control, diabetic with 30 days (D30) and 60 days (D60) after Streptozotocin-induced diabetes. The isolated left and right atria were used in functional experiments. The effects of ATP, UDP and adenosine were evaluated on atrial inotropism and chronotropism. The antagonists DPCPX and PPADS were also used, as blockers of P1 and P2 receptors respectively. A negative inotropic effect followed by a positive inotropic effect was induced by ATP in isolated atria. This negative inotropic effect was decreased by 25% in left atria of D30. Additionally, the apparent affinity for adenosine was diminished in left atria of D30 suggesting changes in P1 receptor function. No changes were found in the right atria of D30 stimulated by adenosine. The left atria and right atria stimulated by UDP, showed an increased of inotropic effect, 92% and 17% respectively. No changes were observed in left and right atria of D30 stimulated by UDP. Our data showed the involvement of purinergic neurotransmission in diabetes-related cardiovascular changes.
Diego Castro Musial; Kleber de Magalhães Galvão; Regiane Miranda-Ferreira; Edilson Dantas da Silva Júnior; Afonso Caricati-Neto; Neide Hyppolito Jurkiewicz; Aron Jurkiewicz; Ana Carla Broetto Biazon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-6
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Pharmacology, Federal University of São Paulo, São Paulo, Brazil 2Department of Science Pharmaceutical, Integrado College of Campo Mourão, Paraná, Brazil.
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