Document Detail

Alteration of pancreatic enzyme activities in small intestine of rats fed a high fructose, low copper diet.
MedLine Citation:
PMID:  2442328     Owner:  NLM     Status:  MEDLINE    
This study describes the progressive effects on pancreatic enzyme activities from washings of the small intestine of rats fed diets containing either 62% starch (S) or fructose (F), with 0.6 mg copper/kg diet (-Cu) or 6.0 mg copper/kg diet (+Cu) from 21 to 61 d of age. Hepatic copper concentration of the copper-deficient groups was 50% of that of the copper-supplemented groups. Body and relative pancreatic weights were lower in the F-Cu dietary group than in any other group. Relative liver weight was significantly higher in the fructose dietary groups than in the starch dietary groups. There were significant carbohydrate (CHO) X week and Cu X week interactions for luminal amylase activities and the CHO X Cu X week interaction was significant for luminal lipase and trypsin activities. The lowest enzyme activities were observed in the F-Cu-fed rats. The CHO X week interaction was significant for chymotrypsin with the lowest enzyme activities in the fructose-fed rats. It appears that high dietary fructose and low dietary copper interact to produce greatly reduced pancreatic enzyme activities in small intestinal washings. We speculate that subsequent digestive and absorptive abnormalities during a period of rapid growth may account for the severe morbidity and mortality in copper-deficient, fructose-fed rats.
C G Lewis; M Fields; N Craft; C Y Yang; S Reiser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  117     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-10-16     Completed Date:  1987-10-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1447-52     Citation Subset:  IM    
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MeSH Terms
Amylases / metabolism
Body Weight / drug effects
Chymotrypsin / metabolism
Copper / deficiency*,  metabolism
Dietary Carbohydrates / administration & dosage,  pharmacology*
Fructose / administration & dosage,  pharmacology*
Intestine, Small / drug effects,  enzymology*
Lipase / metabolism
Pancreas / drug effects,  enzymology*
Rats, Inbred Strains
Starch / pharmacology
Trypsin / metabolism
Reg. No./Substance:
0/Dietary Carbohydrates; 30237-26-4/Fructose; 7440-50-8/Copper; 9005-25-8/Starch; EC; EC 3.2.1.-/Amylases; EC; EC

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