| Alteration of odontoblast osteonectin expression following dental cavity preparation. | |
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MedLine Citation:
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PMID: 11420055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cavity preparation can increase the active synthesis and secretion of non-collagenous proteins by odontoblasts, thus resulting in the deposition of tertiary dentine. In this study, the effect of cavity preparation on osteonectin expression was examined in odontoblasts of the rat tooth pulp. A class V cavity was prepared in rat first molars to stimulate odontoblastic secretory activity, and the animals were killed at various intervals. In the normal pulp, osteonectin immunoreactivity was detected in odontoblasts but not other cells. At 1 day after cavity preparation, immunoreactivity had diminished beneath the cavity. At 3 days, strong immunoreactivity could be detected in odontoblasts beneath the cavity. Numerous round cells underlying the odontoblastic layer also demonstrated immunoreactivity. Thereafter, the intensity of osteonectin immunoreactivity in odontoblasts beneath tertiary dentine decreased gradually, and at 30 and 60 days, it was weaker than in normal pulp. These findings suggest that osteonectin is actively synthesized by odontoblasts underlying a cavity in the initial stage of tertiary dentine formation. |
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Authors:
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T Itota; Y Nishitani; N Sogawa; C Sogawa; N Konishi; Y Torii |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of oral biology Volume: 46 ISSN: 0003-9969 ISO Abbreviation: Arch. Oral Biol. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-06-22 Completed Date: 2001-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0116711 Medline TA: Arch Oral Biol Country: England |
Other Details:
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Languages: eng Pagination: 829-34 Citation Subset: D; IM |
Affiliation:
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Department of Operative Dentistry, Okayama University Dental School, 2-5-1 Shikata-cho, 700-8525, Okayama, Japan. itota@md.okayama-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Densitometry Dental Cavity Preparation* Dental Pulp / cytology, metabolism Dentin, Secondary / secretion Fluorescent Antibody Technique, Indirect Immunohistochemistry Male Odontoblasts / metabolism* Osteonectin / biosynthesis* Rats Rats, Sprague-Dawley Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Osteonectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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