Document Detail


Alteration of mammalian-cell toxicity of pesticides by structural iron(II) in ferruginous smectite.
MedLine Citation:
PMID:  15382868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ultimate concern over pesticides in the environment is their toxic impact on nontarget organisms, including humans. Soil clays are known to interact with pesticides in ways that decrease the concentration of the parent compound in the soil solution (adsorption, sequestration, degradation). These phenomena are generally regarded as beneficial, but toxicological verification is lacking. In this study, mammalian-cell cytotoxicity of four commonly used agricultural chemicals (2,4-D, alachlor, dicamba, and oxamyl) was assessed after exposure to either reduced or oxidized ferruginous smectite (SWa-1). Results revealed that treatment with reduced smectite produced differential effects on mammalian-cell viability, depending on the pesticide. Oxamyl and alachlor reacted with reduced SWa-1 showed a significant decrease in their overall cytotoxic potential. Dicamba reacted with the reduced-clay treatment and generated products that were more toxic than the parent pesticide. Finally, no differences were observed between redox treatments for 2,4-D. The significance of these results is that oxidized smectites have virtually no influence on the toxicity of pesticides, whereas reduced-Fe smectite plays an important role in altering the cytotoxic potential of agricultural pesticides. The Fe oxidation state of clay minerals should, therefore, be taken into account in pesticide management programs.
Authors:
Kara C Sorensen; Joseph W Stucki; Richard E Warner; Michael J Plewa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  38     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-22     Completed Date:  2004-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4383-9     Citation Subset:  IM    
Affiliation:
Department of Natural Resources and Environmental Sciences University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Agriculture
Aluminum Silicates
Animals
CHO Cells
Cricetinae
Iron / chemistry
Oxidation-Reduction
Pesticides / chemistry,  toxicity*
Silicates / chemistry*
Toxicity Tests
Chemical
Reg. No./Substance:
0/Aluminum Silicates; 0/Pesticides; 0/Silicates; 12199-37-0/Smectite; 1302-87-0/clay; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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