Document Detail

Alteration in vaginal microflora, douching prior to pregnancy, and preterm birth.
MedLine Citation:
PMID:  19000290     Owner:  NLM     Status:  MEDLINE    
We aimed to determine the relationship of douching prior to pregnancy and bacterial vaginosis (BV) during pregnancy on preterm birth, addressing individual and joint effects. We used a prospective cohort study and assessed vaginal microflora using gram stains and Nugent's criteria. Douching behaviour was based on self-report about the 12 months prior to pregnancy. Preterm births were categorised as spontaneous or medically indicated. A total of 2561 women provided vaginal specimens and 1492 provided self-reports on douching behaviour. Bacterial vaginosis assessed at 24-28 weeks' gestation in the absence of douching prior to pregnancy was associated with spontaneous preterm birth (odds ratio = 2.74 [95% confidence interval 1.13, 6.66]) as was douching in the absence of BV (OR = 2.20 [1.29, 3.75]). The combination of BV and douching was unrelated to spontaneous or medically indicated preterm birth. We concluded that acute alterations in vaginal microflora at mid-pregnancy or douching prior to pregnancy were associated with an increased risk of preterm birth, but the combination did not appear to increase the risk further than would be expected.
John M Thorp; Nancy Dole; Amy H Herring; Thaddeus L McDonald; Barbara Eucker; David A Savitz; Diane Kaczor
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  22     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-01-28     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  530-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599-7516,
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MeSH Terms
Cohort Studies
Gram-Positive Bacteria / isolation & purification
Infant, Newborn
Infant, Premature
Logistic Models
Premature Birth / epidemiology,  etiology*
Prospective Studies
Vagina / microbiology*
Vaginal Douching / adverse effects*
Vaginosis, Bacterial / etiology*
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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