Document Detail


Alteration in serum neural cell adhesion molecule in patients of schizophrenia.
MedLine Citation:
PMID:  17266166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The neural cell adhesion molecule (N-CAM) plays important roles in neural migration, synaptogenesis and CNS development. Change of N-CAM fragments in CSF of schizophrenic patients was reported previously, and we aimed to detect difference in circulating N-CAM in the serum of schizophrenic patients and healthy controls. METHODS: Samples were from 14 chronic schizophrenic patients including 3 drug naïve patients and 11 healthy controls. After removal of albumin and globulin, N-CAM fragments were measured by Western blot technique with monoclonal antibody. RESULTS: N-CAM immunoreactive bands were detected primarily at 180, 140, 120, 75, 68 and 52 kDa. Samples from patients and controls showed similar patterns of bands, but schizophrenic patients showed increases or decreases at some bands intensity compared to healthy controls. The 68 kDa/73-75 kDa bands intensity ratio was substantially elevated in schizophrenic patients (0.262+/-0.14 in patients, 0.065+/-0.04 in controls) especially, the three drug naïve patients had a higher value of this ratio compared to the medicated patients. One drug naïve patient showed a decrease in this ratio after one month of antipsychotic medication. CONCLUSIONS: The results suggest elevated membrane turnover and/or abnormalities in the regulation of proteolysis of N-CAM in schizophrenia.
Authors:
Yoko Tanaka; Satoshi Yoshida; Yumi Shimada; Hiroshi Ueda; Kunihiko Asai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human psychopharmacology     Volume:  22     ISSN:  0885-6222     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-07-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 John Wiley & Sons, Ltd.
Affiliation:
Asai Hospital, Chiba, and Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Antipsychotic Agents / therapeutic use
Benzodiazepines / therapeutic use
Blotting, Western
Chronic Disease
Dibenzothiazepines / therapeutic use
Female
Humans
Indoles / therapeutic use
Isoindoles
Male
Middle Aged
Molecular Weight
Neural Cell Adhesion Molecules / blood*,  chemistry
Protein Isoforms / blood,  chemistry
Risperidone / therapeutic use
Schizophrenia / blood*,  drug therapy
Thiazoles / therapeutic use
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/Indoles; 0/Isoindoles; 0/Neural Cell Adhesion Molecules; 0/Protein Isoforms; 0/Thiazoles; 0/quetiapine; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 129273-38-7/perospirone; 132539-06-1/olanzapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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