Document Detail


Alteration in myocardial prostaglandin D synthase expression in pressure overload-induced left ventricular remodeling in rats.
MedLine Citation:
PMID:  22228706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesized that acute pharmacological blockade of cyclooxygenase-2 (COX-2) using nimesulide (Nime) would prevent maladaptive changes in left ventricular (LV) structure and function secondary to abdominal aortic coarctation-induced pressure overload (PO). In vivo LV chamber dimension and function were assessed by pressure/volume admittance catheter at 14 days' postsurgery in three groups (n ≥ 6/group): sham-operated (Sham); untreated PO; and selective COX-2 inhibitor nimesulide-treated PO (PO + Nime; 25 mg/kg/d). Treatment was initiated 24 h prior to surgical induction of PO. Relative to Sham, there was a marked increase in LV mass index in the PO groups (2.2 ± 0.01 mg/g versus 2.9 ± 0.10 mg/g Sham versus PO, PO+Nime: 2.5 ± 0.03 mg/g). End diastolic volume, an indicator of chamber size, was significantly decreased in the PO animals compared with Sham (202 ± 17μL versus 143 ± 16 μL Sham versus PO, PO + Nime: 226 ± 9 μL). Collagen levels in PO rats assessed by hydroxyproline analysis were significantly elevated relative to Sham values. Nimesulide treatment attenuated: (1) the increase in LV mass index; (2) the reduction in end diastolic volume; and (3) the PO-induced increase in myocardial collagen. In summary, acute COX-2 inhibition with nimesulide attenuated the maladaptive changes in the LV after PO. Acknowledging the clinical failure of chronic COX-2 inhibitor use, we propose that acute treatment with COX-2 inhibition during the initial stages of cardiac remodeling can be beneficial in maintaining the normal cardiac structure and function during PO.
Authors:
Krishna T Nagalla; Monica Gole; Mario A Claudino; Jason D Gardner; David B Murray
Related Documents :
6596056 - The role of sodium and potassium in the control of blood pressure.
12624006 - Erythrocyte sodium-lithium countertransport and blood pressure: a genome-wide linkage s...
25443726 - Hypotensive effects of omentin-1 related to increased adiponectin and decreased interle...
10562636 - Biphasic changes in heart performance with food restriction in rats.
12544926 - Cerebral spinal fluid pressure: effects of body position and lumbar subarachnoid draina...
23248216 - Chronic elevation of pulmonary microvascular pressure in chronic heart failure reduces ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-06
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-02-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-30     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Mississippi, University, MS 38677, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Coarctation / physiopathology
Collagen / metabolism
Cyclooxygenase 2 / metabolism
Cyclooxygenase 2 Inhibitors / administration & dosage*
Heart / physiopathology
Heart Diseases / drug therapy*,  pathology,  physiopathology
Heart Ventricles / metabolism
Intramolecular Oxidoreductases / metabolism*
Lipocalins / metabolism*
Male
Myocardium / metabolism,  pathology
Pressure
Rats
Rats, Sprague-Dawley
Sulfonamides / administration & dosage*
Ventricular Function, Left
Ventricular Remodeling / drug effects*
Chemical
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Lipocalins; 0/Sulfonamides; 51803-78-2/nimesulide; 9007-34-5/Collagen; EC 1.14.99.1/Cyclooxygenase 2; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.2/prostaglandin R2 D-isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A custom rat and baboon hypertension gene array to compare experimental models.
Next Document:  Genotoxic stress and activation of novel DNA repair enzymes in the endothelial cells and in the reti...