| Alteration in myocardial prostaglandin D synthase expression in pressure overload-induced left ventricular remodeling in rats. | |
| | |
MedLine Citation:
|
PMID: 22228706 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We hypothesized that acute pharmacological blockade of cyclooxygenase-2 (COX-2) using nimesulide (Nime) would prevent maladaptive changes in left ventricular (LV) structure and function secondary to abdominal aortic coarctation-induced pressure overload (PO). In vivo LV chamber dimension and function were assessed by pressure/volume admittance catheter at 14 days' postsurgery in three groups (n ≥ 6/group): sham-operated (Sham); untreated PO; and selective COX-2 inhibitor nimesulide-treated PO (PO + Nime; 25 mg/kg/d). Treatment was initiated 24 h prior to surgical induction of PO. Relative to Sham, there was a marked increase in LV mass index in the PO groups (2.2 ± 0.01 mg/g versus 2.9 ± 0.10 mg/g Sham versus PO, PO+Nime: 2.5 ± 0.03 mg/g). End diastolic volume, an indicator of chamber size, was significantly decreased in the PO animals compared with Sham (202 ± 17μL versus 143 ± 16 μL Sham versus PO, PO + Nime: 226 ± 9 μL). Collagen levels in PO rats assessed by hydroxyproline analysis were significantly elevated relative to Sham values. Nimesulide treatment attenuated: (1) the increase in LV mass index; (2) the reduction in end diastolic volume; and (3) the PO-induced increase in myocardial collagen. In summary, acute COX-2 inhibition with nimesulide attenuated the maladaptive changes in the LV after PO. Acknowledging the clinical failure of chronic COX-2 inhibitor use, we propose that acute treatment with COX-2 inhibition during the initial stages of cardiac remodeling can be beneficial in maintaining the normal cardiac structure and function during PO. |
| | |
Authors:
|
Krishna T Nagalla; Monica Gole; Mario A Claudino; Jason D Gardner; David B Murray |
Related Documents
:
|
7902336 - Increased dietary salt sensitizes vasomotor neurons of the rostral ventrolateral medulla. 2447016 - Repetitive natriuresis and blood pressure. long-term calcium entry blockade with isradi... 7645536 - Acute decreases in serum potassium augment blood pressure. 870266 - Cramps, thirst and hypertension in hemodialysis patients -- the influence of dialyzate ... 10710186 - Interstitial fluid pressurization during confined compression cyclical loading of artic... 10535516 - Balloon dilation of right ventricular outflow tract in a dog with tetralogy of fallot. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-6 |
Journal Detail:
|
Title: Experimental biology and medicine (Maywood, N.J.) Volume: - ISSN: 1535-3699 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pharmacology, University of Mississippi, University, MS 38677. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A custom rat and baboon hypertension gene array to compare experimental models.
Next Document: Genotoxic stress and activation of novel DNA repair enzymes in the endothelial cells and in the reti...