| Alteration in lipid profile in patients of chronic myeloid leukemia before and after chemotherapy. | |
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MedLine Citation:
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PMID: 16386722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pleuripotent hematopoietic progenitor cells characterized by excessive proliferation and accumulation of granulocytes and occasionally red blood cells and platelets. METHODS: We examined 30 newly diagnosed and proved cases of CML admitted in medical wards or attending a clinical hematology clinic. In addition to routine hematological investigations, lipid profile was done in all the patients at the time of presentation, 4-6 weeks after the start of chemotherapy and 6 months after the chemotherapy even if some of the patients were not in remission. RESULTS: Total serum cholesterol, HDL-cholesterol and LDL-cholesterol concentrations increased significantly after chemotherapy whereas serum triglyceride and VLDL-C cholesterol concentrations did not increase significantly. Also, lipid concentrations were correlated with disease activity. An inverse correlation was found with spleen size and total serum cholesterol, HDL-cholesterol and LDL-cholesterol. Serum triglyceride and VLDL-C concentrations were inversely related to the hemoglobin concentrations. There was no correlation of total cholesterol and LDL-cholesterol concentrations with hemoglobin. We found from the present study that low lipid concentrations are associated with poor prognosis of the disease. CONCLUSION: We suggest that the estimation of lipid profile may be helpful in evaluating the response to chemotherapy in CML patients. |
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Authors:
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Veena S Ghalaut; Manju B Pahwa; Sunita; P S Ghalaut |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-12-28 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 366 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-06-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 239-42 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India. manjupahwadoc1@yahoo.co.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Cholesterol, VLDL / blood Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood*, drug therapy Lipids / blood* Male Middle Aged Remission Induction Time Factors Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol |
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