| Alteration in gastrointestinal peptides after thermal injury in humans. | |
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MedLine Citation:
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PMID: 8300701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alterations in gastrointestinal function are common after thermal injury in humans. The peptide hormones gastrin and cholecystokinin are known to exert effects on gastric and biliary motility and on secretory function and to induce trophic changes in gut mucosa. The effect of injury on these hormones has received little attention. Six patients with burns were studied while receiving a combination of regular diet and continuous enteral feeding. Four healthy members of the nursing staff served as the control group. Blood was drawn every 4 hours for 24 hours. Gastrin and cholecystokinin were analyzed by radioimmunoassay. Patients with burns demonstrated significantly higher levels of gastrin and lower levels of cholecystokinin when compared with the control group. Patients with burns also failed to demonstrate the normal circadian variation in these peptides. |
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Authors:
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J B Cone; J N Pasley; P J Bond; D W McKay; P L Rayford |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 14 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1993 Nov-Dec |
Date Detail:
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Created Date: 1994-03-10 Completed Date: 1994-03-10 Revised Date: 2006-08-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 663-5 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Arkansas for Medical Sciences, Little Rock 72205. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Burns / metabolism*, physiopathology, therapy Cholecystokinin / blood, metabolism* Circadian Rhythm / physiology Enteral Nutrition Gastrins / blood, metabolism* Humans Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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