| Alteration in the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies. | |
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MedLine Citation:
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PMID: 16629770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We investigated whether mutation of mitochondrial DNA (mtDNA) affects the copy number of the mitochondrial genome in patients with mitochondrial myopathy encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and those with myoclonic epilepsy with ragged-red fiber (MERRF) syndromes. MATERIALS AND METHODS: Forty-eight Taiwanese patients with MELAS syndrome and 20 patients with MERRF syndrome were recruited in this study. RESULTS: In relation to controls, the copy numbers of mtDNA in leukocytes of patients with MELAS or MERRF syndrome were significantly higher at a young age but lower at an advanced age. In addition, MELAS patients harboring higher proportions of mtDNA with A3243G transition had lower mtDNA copy numbers. The MELAS or MERRF patients with multi-system disorders had lower mtDNA copy numbers in leukocytes. Furthermore, higher proportions of mtDNA with 4977 bp deletion were found in leukocytes of MERRF patients with multi-system involvement. CONCLUSION: In leukocytes, alteration in the copy number of mtDNA is related to the proportion of mtDNA with a point mutation or large-scale deletion, which may serve as a biomarker in the pathogenesis and disease progression of MELAS and MERRF syndromes. |
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Authors:
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C-S Liu; W-L Cheng; C-F Lee; Y-S Ma; C-Y Lin; C-C Huang; Y-H Wei |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 113 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-24 Completed Date: 2006-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 334-41 Citation Subset: IM |
Affiliation:
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Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Case-Control Studies DNA, Mitochondrial / genetics* Female Gene Dosage / genetics Genes, Mitochondrial / genetics Humans Leukocytes / physiology* MELAS Syndrome / genetics* MERRF Syndrome / genetics* Male Middle Aged Mutation / genetics* Polymerase Chain Reaction Severity of Illness Index Taiwan |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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