Document Detail

Alteration in brain metabolites of jirds infected with alveolar Echinococcus.
MedLine Citation:
PMID:  9267426     Owner:  NLM     Status:  MEDLINE    
The Meriones unguiculatus-Echinococcus multilocularis host-parasite system was used to evaluate changes in metabolite levels in the brain of the infected host. Nuclear magnetic resonance analysis of perchloric acid extracts of the entire brain of jirds revealed that infection caused a change in the concentration of several metabolites, especially those that serve as amino acidergic neurotransmitters in this organ. The concentrations of the neuroexcitatory compounds glutamate and aspartate and the neuroinhibitory compounds glycine and taurine were significantly reduced. Those of 2 other amino acids, glutamine and alanine, were also decreased. In addition, concentrations of glycerophosphocholine and phosphocholine were also lower, whereas those of phosphocreatine and N-acetylaspartate were elevated.
A Modha; M Novak; B J Blackburn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of parasitology     Volume:  83     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-02     Completed Date:  1997-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  764-6     Citation Subset:  IM    
Department of Biology, University of Winnipeg, Manitoba, Canada.
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MeSH Terms
Amino Acids / metabolism
Brain / metabolism*
Echinococcosis, Hepatic / metabolism*
Magnetic Resonance Spectroscopy
Neurotransmitter Agents / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Neurotransmitter Agents

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