Document Detail

Alteration in T cell subset phenotypes as cell markers for rejection or long-term allograft acceptance in allografted rats treated with antithymocyte globulin.
MedLine Citation:
PMID:  8353464     Owner:  NLM     Status:  MEDLINE    
The alterations in the absolute levels of lymphocyte phenotype subsets were measured in a rat model for heart allograft acceptance induced by antithymocyte globulin (ATG). In untreated, allografted rats all T lymphocytes decreased with 50% within 3 days after transplantation and recovered within 1 week. ATG alone induced a depletion of 75% of the T lymphocytes, which did not normalise until 60 days after treatment. During the first 10 days, ATG-treated rats with an accepted allograft had higher levels of T lymphocytes than those with rejections while the T lymphocytes recovered faster after day 10 in the later rats. The study demonstrates different alterations in T lymphocytes phenotype subsets between rejecting rats and rats with long-term accepted allograft. It also shows that the operation trauma with rejection as well as the ATG treatment strongly influence the T cell subsets.
M Olausson; L Wramner; B Kjellson; L Mjörnstedt; T Söderström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  101     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-09-23     Completed Date:  1993-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Department of Surgery, Sahlgrenska Hospital, University of Göteborg, Sweden.
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MeSH Terms
Antilymphocyte Serum / therapeutic use*
Graft Rejection / pathology*
Graft Survival / drug effects*
Heart Transplantation / immunology
Models, Biological
Rats, Inbred Strains
T-Lymphocyte Subsets / cytology*,  drug effects
Transplantation, Homologous / immunology
Reg. No./Substance:
0/Antilymphocyte Serum

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