| Alteration of hepatic acetylation in uraemia. | |
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MedLine Citation:
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PMID: 1197268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rate of acetylation of sulphadimidine was estimated in 25 normals and in two groups of patients on intermittent haemodialysis. Group A consisted of nine patients who were about to commence or had already been on dialysis for less than one year. Group B consisted of eight patients dialysed for one to six years. There was a highly significant increase in the incidence of fast acetylators in group A (p less than 0.001) compared with a normal population. There is an alteration of hepatic acetylation in chronic uraemia. This trend appears to be reversed by prolonged intermittent dialysis. Alteration of hepatic metabolism may indicate an important compensatory role for the liver in uraemia. |
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Authors:
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A Fine; D Sumner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Volume: 11 ISSN: 0071-2736 ISO Abbreviation: Proc Eur Dial Transplant Assoc Publication Date: 1975 |
Date Detail:
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Created Date: 1976-02-19 Completed Date: 1976-02-19 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0355210 Medline TA: Proc Eur Dial Transplant Assoc Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 433-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Administration, Oral Humans Injections, Intravenous Kidney / metabolism Kinetics Liver / metabolism* Protein Binding Sulfamethazine / metabolism* Uremia / metabolism* |
| Chemical | |
Reg. No./Substance:
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57-68-1/Sulfamethazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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