Document Detail

Alteration of hepatic acetylation in uraemia.
MedLine Citation:
PMID:  1197268     Owner:  NLM     Status:  MEDLINE    
The rate of acetylation of sulphadimidine was estimated in 25 normals and in two groups of patients on intermittent haemodialysis. Group A consisted of nine patients who were about to commence or had already been on dialysis for less than one year. Group B consisted of eight patients dialysed for one to six years. There was a highly significant increase in the incidence of fast acetylators in group A (p less than 0.001) compared with a normal population. There is an alteration of hepatic acetylation in chronic uraemia. This trend appears to be reversed by prolonged intermittent dialysis. Alteration of hepatic metabolism may indicate an important compensatory role for the liver in uraemia.
A Fine; D Sumner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  11     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-19     Completed Date:  1976-02-19     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Injections, Intravenous
Kidney / metabolism
Liver / metabolism*
Protein Binding
Sulfamethazine / metabolism*
Uremia / metabolism*
Reg. No./Substance:

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