Document Detail

Alteration of guinea pig erythrocyte superoxide dismutase activity by dietary antioxidants.
MedLine Citation:
PMID:  3733337     Owner:  NLM     Status:  MEDLINE    
An improved method for the measurement of superoxide dismutase (SOD) activity in guinea pig erythrocytes was developed. Alteration of guinea pig erythrocyte superoxide dismutase activity by the dietary antioxidants ascorbic acid and selenium was investigated. Erythrocyte SOD activity was directly related to the ascorbic acid intake of guinea pigs fed 0.05 ppm of selenium. Dietary levels of ascorbic acid were 0, 200 and 400 mg/kg). In guinea pigs fed 0.20 ppm of selenium, there was an increase in superoxide dismutase activity only in the group of animals fed the 400 mg ascorbic acid/kg of diet. Results suggest that substantial protection from deleterious O2-. can be provided by changes in dietary ascorbic acid.
S T Omaye; B D Potter; B P Poovaiah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  56     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  1986  
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
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MeSH Terms
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Erythrocytes / enzymology*
Guinea Pigs
Selenium / pharmacology
Superoxide Dismutase / blood*
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid; 7782-49-2/Selenium; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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