Document Detail


Alteration of global workspace during loss of consciousness: A study of parietal seizures.
MedLine Citation:
PMID:  23016829     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose:  Loss of consciousness (LOC) in epileptic seizures has a strongly negative impact on quality of life. Recently, we showed that LOC occurring during temporal lobe seizures was correlated with a nonlinear increase of neural synchrony in associative-and particularly parietal-cortices. Whether these mechanisms might be observed in other types of seizures is unknown. This study aimed at investigating the relationship between changes in synchrony and degree of LOC during parietal lobe epilepsy (PLE), a form of epilepsy in which seizures directly involve the parietal associative cortices. Methods:  Ten patients undergoing stereoelectroencephalography (SEEG) during presurgical evaluation of PLE were studied. The LOC intensity was scored using the Conscious Seizure Scale (CSS). For each studied seizure (n = 29), interdependencies between signals recorded from six brain regions were estimated as a function of time by using nonlinear regression analysis (h(2) coefficient). Key Findings:  Seizures were divided into three groups according to the CSS scale: group A (no LOC) with a score ≤1, group B (intermediate or partial LOC) with a score ranging from 2 to 5, and group C (maximal LOC) with a score ≥6. The majority of seizures in patients with PLE disclosed significant LOC (17/29, group C). Mean h(2) values were significantly different between the three groups (p = 0.008), the maximal values of synchrony being observed in group C. In addition, a statistically significant nonlinear relationship (p = 0.0021) was found between the h(2) values and the CSS scores, suggesting a threshold effect. Significance:  This study indicates that excess of EEG signal synchrony within associative cortices is likely to be a crucial phenomenon associated with LOC.
Authors:
Isabelle Lambert; Marie Arthuis; Aileen McGonigal; Fabrice Wendling; Fabrice Bartolomei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Epilepsia     Volume:  -     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International League Against Epilepsy.
Affiliation:
CHU Timone, Service de Neurophysiologie Clinique, Assistance Publique des Hôpitaux de Marseille, Marseille, France Institut de Neurosciences des Systèmes, Inserm UMR, Marseille, France Inserm, Université Rennes 1, Rennes, France Hôpital Henri Gastaut/Centre Saint-Paul, Cinapse, 300 Bd Sainte-Marguerite, Marseille, France.
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