Document Detail


Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism.
MedLine Citation:
PMID:  886474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of pregnant mice with delta 9-tetrahydrocannabinol (THC) significantly increased the incidence of in utero deaths. SKF-525A pretreatment increased the incidence of THC-induced in utero deaths. THC also significantly reduced the body weight of surviving fetuses. Phenobarbital treatment antagonized THC-induced reduction of fetal body weight, but did not reduce resorption rate. Administration of THC, 50 or 200 mg/kg, did not induce fetal anomalies. However, both SKF-525A and phenobarbital treatment potentiated THC-induced cleft palates. SKF-525A treatment plus THC produced 36% cleft palates. Phenobarbital treatment plus THC produced 77% cleft palates. Pretreatments altered the level of tetrahydrocannabinol plus metabolites found in plasma, placenta, fetus and amnionic fluid. In general, SKF-525A increased levels and phenobarbital decreased levels. Two chemically reactive metabolites of THC are proposed, 9,10-epoxyhexahydrocannabinol and an 11-oxo derivative. SKF-525A pretreatment increased the concentration of both of these metabolites. Phenobarbital treatment increased the levels of the proposed 9,10-epoxyhexahydrocannabinol. Possible covalent binding of THC was observed. An active metabolite theory may apply to the teratogenic properties of THC.
Authors:
R D Harbison; B Mantilla-Plata; D J Lubin
Related Documents :
17516184 - Searching the silver trail: charles van onselen, joe silver and jack the ripper.
25229824 - Diving and pregnancy: what do we really know?
25026404 - Some thoughts on the mechanical anatomy of the female pelvis.
25260124 - Experimental fetal endoscopic tracheal occlusion in rhesus and cynomolgus monkeys: nonh...
22687324 - Relationship between psychological stress and recurrent miscarriage.
23803754 - Fetal dysrhythmias: a primer for the obstetrician/gynecologist.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  202     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-65     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / metabolism
Animals
Body Weight / drug effects
Cleft Palate / chemically induced
Drug Interactions
Female
Fetal Death / chemically induced
Fetus / drug effects,  metabolism
Gestational Age
Maternal-Fetal Exchange
Mice
Phenobarbital / pharmacology
Placenta / metabolism
Pregnancy
Proadifen / pharmacology
Teratogens / metabolism*
Tetrahydrocannabinol / blood,  metabolism,  pharmacology*
Chemical
Reg. No./Substance:
0/Teratogens; 1972-08-3/Tetrahydrocannabinol; 302-33-0/Proadifen; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The analgesic action of baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid].
Next Document:  Morphological, cytological, and biochemical changes of Anguilla anguilla L. gills deprived of Stanni...