| Alteration of cytochrome P-450 2C11-dependent testosterone metabolism in Gunn rat liver. | |
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MedLine Citation:
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PMID: 1472535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytochrome P-450 2C11 (CYP2C11) is the main isozyme present in adult male rat liver and specifically hydroxylates testosterone in positions 2 alpha and 16 alpha. In Gunn rats, this isozyme is recognized by the anti-CYP2C11 antibody but its activity towards testosterone is dramatically decreased. Moreover, peptide mapping, after digestion of microsomal fractions by V8 protease and probing with anti-CYP2C11 antibody, exhibit a pattern which differs from that obtained with Wistar rats. Taken together, data suggest that the protein sequence of CYP2C11 from the Gunn rat differs from that of the Wistar rat. |
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Authors:
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C Célier; S Columelli; T Cresteil |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1156 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-02-03 Completed Date: 1993-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 15-8 Citation Subset: IM |
Affiliation:
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INSERM U75, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies Aryl Hydrocarbon Hydroxylases* Cytochrome P-450 Enzyme System / immunology, metabolism* Endopeptidases Liver / enzymology* Male Peptide Mapping Rats Rats, Gunn Rats, Wistar Steroid Hydroxylases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.-/Steroid Hydroxylases; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/testosterone 7-alpha-hydroxylase, hamster; EC 3.4.-/Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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