| Alteration of collagenous protein profile in congestive heart failure secondary to myocardial infarction. | |
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MedLine Citation:
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PMID: 8177234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rat model of myocardial infarction is characterized by progressive cardiac hypertrophy and failure. Rats with infarcts greater than 30% of the left ventricle exhibited early and moderate stages of heart failure 4 and 8 weeks after the occlusion of the left coronary artery, respectively. As heart failure is usually associated with remodeling of the extracellular matrix, a histological and biochemical study of cardiac collagenous proteins was carried out using failing hearts. Total collagen content in the right ventricle increased at 2, 4, and 8 weeks following occlusion of the left coronary artery whereas such a change in viable left ventricle was seen after 4 and 8 weeks. Total cardiac hydroxyproline concentration was increased in both right and left ventricular samples from the infarcted animals when compared to those of control; this increase was due to elevation of pepsin-insoluble collagen fraction. The myocardial noncollagenous/collagenous protein ratio was decreased in experimental right and left ventricular samples when compared to control samples. These findings suggest that an increase in cross-linking of cardiac collagen as well as disparate synthesis of collagenous and noncollagenous proteins occurs in this model of congestive heart failure. |
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Authors:
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V Pelouch; I M Dixon; R Sethi; N S Dhalla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 129 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-06-07 Completed Date: 1994-06-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 121-31 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collagen / metabolism* Heart Failure / etiology, metabolism*, pathology Male Myocardial Infarction / complications, metabolism*, pathology Rats Rats, Sprague-Dawley Solubility |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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