| Alteration of cell fate by ectopic expression of Drosophila glial cells missing in non-neural cells. | |
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MedLine Citation:
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PMID: 9811976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The glial cells missing (gcm) gene encodes an essential transcription factor that converts neuronal precursor cells to glial fate in the Drosophila nervous system. In this study, we tested effects of gcm ectopic expression on fate of non-neural cells. When gcm expression was continuously induced in epidermal cells from around stage 9, these cells started to exhibit mesenchymal cell morphology at stage 13, which was preceded by the onset of expression of Repo, a glial marker. The morphological change was coincident with loss of expression of an epidermal cell-adhesion molecule. In addition to the epidermis, fate of mesodermal cells was also affected by gcm ectopic expression. These findings suggest that gcm can convert gene expression and cell morphology even outside the neuroectoderm. |
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Authors:
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Y Akiyama-Oda; T Hosoya; Y Hotta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development genes and evolution Volume: 208 ISSN: 0949-944X ISO Abbreviation: Dev. Genes Evol. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-02-01 Completed Date: 1999-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9613264 Medline TA: Dev Genes Evol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 578-85 Citation Subset: IM |
Affiliation:
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Department of Physics, Graduate School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA-Binding Proteins Drosophila Proteins* Drosophila melanogaster / cytology, embryology*, genetics* Ectoderm / cytology, metabolism Gene Expression Regulation, Developmental Genes, Insect* Homeodomain Proteins / genetics, metabolism Hu Paraneoplastic Encephalomyelitis Antigens Immunohistochemistry Insect Proteins / genetics, metabolism Mesoderm / cytology, metabolism Neuroglia / cytology, metabolism Neuropeptides / genetics*, metabolism Ribonucleoproteins / genetics, metabolism Trans-Activators / genetics*, metabolism Transcription Factors |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/GCM protein, Drosophila; 0/Homeodomain Proteins; 0/Hu Paraneoplastic Encephalomyelitis Antigens; 0/Insect Proteins; 0/Neuropeptides; 0/Ribonucleoproteins; 0/Trans-Activators; 0/Transcription Factors; 0/repo protein, Drosophila |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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