Document Detail

Alteration of the QT rate dependence in anorexia nervosa.
MedLine Citation:
PMID:  15305959     Owner:  NLM     Status:  MEDLINE    
Myocardial repolarization has been evaluated in patients with anorexia nervosa (AN) with conflicting results. The authors postulated that dynamic alterations in QT interval adaptation could characterize these patients. This study compared QT dynamicity along RR intervals from 24-hour ECG data of patients with and without AN. Twenty-five patients (23 women) fulfilling the Diagnostic and Statistical Manual (DSM IV) criteria for AN were included in the study. All underwent 24-hour ECG Holter recordings, allowing QT and RR measurements, and heart rate variability (HRV) analysis in free-living conditions. A group of 25 sex- and age-matched healthy subjects served as controls. Compared with controls, AN patients presented with relative bradycardia, more particularly during night periods but neither mean QT nor corrected mean QT length (calculated using Bazett formula) over the 24 hours of monitoring differed. However, QT/RR slope was found significantly enhanced compared with normals (-2.00 +/- 0.53 vs - 1.42 +/- 0.40) (P = 0.006): QT length related to heart rate was found longer for a heart rate <55 beats/min in AN. Mean 24-hours QT length appears unaltered in AN in the absence of electrolytic disorders. However, the QT/RR relationship was enhanced reflecting the specific autonomic imbalance encountered in this population. The clinical implications of such findings need to be discussed since an equivalent enhancement of QT/RR slope has been described after myocardial infarction in patients presenting life-threatening ventricular arrhythmias.
Frédéric Roche; Bruno Estour; Myriam Kadem; Luc Millot; Vincent Pichot; David Duverney; Jean-Michel Gaspoz; Jean-Claude Barthélémy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  27     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-12     Completed Date:  2004-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1099-104     Citation Subset:  IM    
Laboratoire de Physiologie, Groupe PhysioPathologie Exercice et Handicap, Groupe de Recherche SYNAPSE, Service d'Exploration Fonctionnelle CardioRespiratoire, CHU Nord, Saint-Etienne, France.
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MeSH Terms
Anorexia Nervosa / physiopathology*
Autonomic Nervous System / physiopathology
Electrocardiography, Ambulatory*
Heart / physiopathology*
Heart Rate / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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