| Alteration of ERβ gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence. | |
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MedLine Citation:
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PMID: 21132001 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This paper aims to determine the possible role of estrogen receptor-β (ERβ) gene RsaI polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited: in vitro fertilization (IVF) group, including 374 couples who underwent conventional IVF; intracytoplasmic sperm injection (ICSI) group, including 294 couples who underwent an ICSI procedure using ejaculated sperm; and azoospermic group, consisting of 197 couples who underwent ICSI using either testis or epididymis sperm. RsaI polymorphism in the ERβ gene was detected by polymerase chain reaction (PCR)-restriction fragment length polymorphism technique; fertilization and high-quality embryo rates were evaluated for each group. In each group, no significant differences were found in the overall rates of fertilization and high-quality embryos among GG, AG and AA genotypes. However, the proportion of cycles possessing a satisfactory high-quality embryo rate with the AA genotype was significantly lower than that in the wild-type GG genotype from each group. These results demonstrated that sperm possessing the ERβ RsaI A genotype may have reduced fertilization ability and decreased early embryonic developmental potential, which could directly or indirectly contribute to the low fertilization rate and early embryonic developmental arrest in some cases. |
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Authors:
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Qiu-Fang Zhang; Huai-Liang Feng; Lan Zhao; Ping Liu; Li Li; Jie Yan; Jie Qiao |
Publication Detail:
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Type: Journal Article Date: 2010-12-06 |
Journal Detail:
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Title: Asian journal of andrology Volume: 13 ISSN: 1745-7262 ISO Abbreviation: Asian J. Androl. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100942132 Medline TA: Asian J Androl Country: China |
Other Details:
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Languages: eng Pagination: 317-21 Citation Subset: IM |
Affiliation:
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Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 1000191, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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