Document Detail

Alstonia species: are they effective in malaria treatment?
MedLine Citation:
PMID:  8246529     Owner:  NLM     Status:  MEDLINE    
A review of the literature on Alstonia species indicates that evidence in support of their effectiveness in the treatment of malaria is controversial. The antiprotozoal activity of the major alkaloid present in Alstonia species, echitamine, was assessed in vitro against Plasmodium falciparum and Giardia intestinalis. Echitamine displayed little antiplasmodial activity, but two quinoline alkaloids from A. coriacea (corialstonine and corialstonidine) were found to have some activity against P. falciparum although this was approximately 10 times less than that of quinine. None of the three Alstonia alkaloids was active against G. intestinalis. These results are discussed in the context of previously published data.
C W Wright; D Allen; J D Phillipson; G C Kirby; D C Warhurst; G Massiot; L Le Men-Olivier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  40     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-01-05     Completed Date:  1994-01-05     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Department of Pharmacognosy, School of Pharmacy, London, UK.
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MeSH Terms
Alkaloids / isolation & purification,  pharmacology*
Antimalarials / pharmacology*
Giardia lamblia / drug effects*
Malaria / drug therapy*
Plant Extracts / pharmacology
Plasmodium falciparum / drug effects*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Alkaloids; 0/Antimalarials; 0/Plant Extracts; 6871-44-9/echitamine

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