| Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. | |
| | |
MedLine Citation:
|
PMID: 21912567 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Topical retinoids inhibit matrix metalloproteinases and accelerate collagen synthesis, thereby triggering antiaging effects in the skin. However, topical retinoids can cause severe skin reactions, including scaling, erythema, papules, and inflammation. The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R. Br. can significantly inhibit all-trans retinoic acid-induced inflammation in human HaCat keratinocyte cells. Furthermore, two representative retinoid-induced proinflammatory cytokines, monocyte chemoattractant protein-1 and interleukin-8, were significantly suppressed by A. scholaris extract (by 82.1% and 26.3% at 100 ppm, and dose-dependently across the tested concentrations) in vitro. In a cumulative irritation patch test, A. scholaris extract decreased retinol-induced skin irritation, while strengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects. These results suggest that A. scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their ability to cause skin irritation. |
| | |
Authors:
|
Soo-Jin Lee; Sun-A Cho; Su-Sun An; Yong-Joo Na; Nok-Hyun Park; Han-Sung Kim; Chan-Woo Lee; Han-Kon Kim; Eun-Kyung Kim; Young-Pyo Jang; Jin-Woong Kim |
Related Documents
:
|
1340277 - Macrophage colony-stimulating factor enhances the respiratory burst of human monocytes ... 15845377 - Pge/camp and gm-csf synergise to induce a pro-tolerance cytokine profile in monocytic c... 1586877 - Haemopoietic growth factors induce human basophil migration in vitro. 16842167 - Hematopoietic colony stimulating factors in cardiovascular and pulmonary remodeling: pr... 15271907 - Characterization of an i-e-restricted, gp63-specific, cd4-t-cell clone from leishmania ... 10850347 - Pha for aplastic anemias: the alpha but not the omega of mitogen therapies. |
Publication Detail:
|
Type: Journal Article Date: 2011-09-08 |
Journal Detail:
|
Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2012 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-09-13 Completed Date: 2011-11-10 Revised Date: 2012-04-26 |
Medline Journal Info:
|
Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: United States |
Other Details:
|
Languages: eng Pagination: 190370 Citation Subset: - |
Affiliation:
|
Amorepacific Co. R&D Center, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do 449-729, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol...
Next Document: Tetraarsenic Hexoxide Induces Beclin-1-Induced Autophagic Cell Death as well as Caspase-Dependent Ap...