Document Detail

Alsmaphorazines A and B, novel indole alkaloids from Alstonia pneumatophora.
MedLine Citation:
PMID:  20735079     Owner:  NLM     Status:  MEDLINE    
Two novel indole alkaloids, alsmaphorazines A and B, were isolated from the leaves of Alstonia pneumatophora (Apocynaceae), and their structures were determined on the basis of the 2D NMR and MS spectral analysis. These alkaloids possessed a new skeleton consisting of an 1,2-oxazinane and an isoxazolidine chromophore. The absolute configuration of alsmaphorazine B was determined by using CD spectral analysis. Alsmaphorazine A inhibited the NO production in the LPS-stimulated J774.1 cells dose-dependently without affecting the cell viability.
Koichiro Koyama; Yusuke Hirasawa; Alfarius Eko Nugroho; Takahiro Hosoya; Teh Chin Hoe; Kit-Lam Chan; Hiroshi Morita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4188-91     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku,Tokyo 142-8501, Japan.
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MeSH Terms
Alstonia / chemistry*
Indole Alkaloids / chemistry*
Models, Molecular
Molecular Structure
Reg. No./Substance:
0/Indole Alkaloids; 0/alsmaphorazine A; 0/alsmaphorazine B

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