Document Detail

Alprazolam in chronic tension type headache.
MedLine Citation:
PMID:  9251377     Owner:  NLM     Status:  MEDLINE    
Alprazolam was evaluated in the treatment of 62 patients of chronic tension type headache using a double blind cross over design with random allocation to drug or placebo. The duration of the trial was 4 months with a 2 week run in period and 2 week washout period separating two treatment periods of 4 weeks each. The patients were followed up for 4 weeks at the completion of the trial. 48 patients completed the trial. There was no significant difference in the overall response rate based in terms of percentage reduction in headache frequency per week, however a significant decrease in headache index was observed during treatment with alprazolam as compared to placebo (P < 0.05). The mean analgesic intake per week was also significantly lower during treatment with alprazolam as compared to the run in period. Side effects were seen in 16.67% patients. In none of the patients was it significant enough to require withdrawal from the study.
R Shukla; D Nag; R C Ahuja
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  44     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-08-29     Completed Date:  1997-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  641-4     Citation Subset:  IM    
Department of Neurology, King George's Medical College, Lucknow.
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MeSH Terms
Alprazolam / adverse effects,  therapeutic use*
Chronic Disease
Cross-Over Studies
Double-Blind Method
Follow-Up Studies
Hypnotics and Sedatives / adverse effects,  therapeutic use*
Tension-Type Headache / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Hypnotics and Sedatives; 28981-97-7/Alprazolam

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