| Alport syndrome with recurrent herpes simplex virus keratitis. | |
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MedLine Citation:
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PMID: 18043194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report a case of Alport syndrome with recurrent herpes simplex virus (HSV) keratitis. METHODS: Case report and review of the literature. RESULTS: A 29-year-old man with Alport syndrome suffered from 4 consecutive episodes of HSV keratitis within 2 years. A type IV collagen defect in basement membranes plays an important role in the pathogenesis of Alport syndrome. The relationship between HSV keratitis and Alport syndrome is discussed. After remission from HSV keratitis, the patient underwent bilateral phacoemulsification and posterior-chamber intraocular lens implantation for anterior lenticonus and an anterior polar cataract. After surgery, the uncorrected visual acuity was 20/20 in both eyes. CONCLUSIONS: We assume that the underlying basement membrane defects in Alport syndrome may account for the recurrent episodes of HSV keratitis in this patient. In addition, phacoemulsification and posterior-chamber intraocular lens implantation, rather than correction of refractive errors, provide a safe and efficient therapeutic choice for the management of anterior lenticonus, with or without associated cataract in patients with Alport syndrome. |
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Authors:
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Pei-Chen Chung; Ken-Kuo Lin; Hu-Shien Song; Wan-Chen Ku; Samuel C M Huang; Chi-Chin Sun |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-28 Completed Date: 2008-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 1279-81 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
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therapeutic use Adult Antiviral Agents / therapeutic use Humans Keratitis, Herpetic / complications*, drug therapy Lens Implantation, Intraocular Male Nephritis, Hereditary / complications* Phacoemulsification Recurrence |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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