Document Detail

Alport syndrome and pregnancy.
MedLine Citation:
PMID:  17267885     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Alport syndrome is a disorder associated with mutations in the type IV collagen gene and manifested by progressive glomerulonephritis. Little is known about the effect of Alport syndrome on pregnancy outcome. CASE: We report a patient with Alport syndrome whose pregnancy was complicated by rapidly progressive severe preeclampsia, fetal growth restriction, and acute renal failure. At 25 weeks of gestation, termination of pregnancy was performed. The patient's renal function was well controlled before pregnancy, but had not recovered at 6 months postpartum, requiring ongoing hemodialysis. CONCLUSION: Alport syndrome in pregnancy has the potential for disease acceleration with rapid parallel progression of vasculopathy in the placental and renal circulations.
Koji Matsuo; Erika L Tudor; Ahmet A Baschat
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  109     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-02-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-2     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology, and Reproductive Science, University of Maryland School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Abortion, Therapeutic
Diagnosis, Differential
Fetal Growth Retardation / diagnosis*
Kidney Failure, Acute / complications,  diagnosis*
Nephritis, Hereditary / complications,  diagnosis*
Pre-Eclampsia / diagnosis*
Pregnancy Trimester, Second
Prenatal Diagnosis*

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