| Alport syndrome and pregnancy. | |
MedLine Citation:
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PMID: 17267885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Alport syndrome is a disorder associated with mutations in the type IV collagen gene and manifested by progressive glomerulonephritis. Little is known about the effect of Alport syndrome on pregnancy outcome. CASE: We report a patient with Alport syndrome whose pregnancy was complicated by rapidly progressive severe preeclampsia, fetal growth restriction, and acute renal failure. At 25 weeks of gestation, termination of pregnancy was performed. The patient's renal function was well controlled before pregnancy, but had not recovered at 6 months postpartum, requiring ongoing hemodialysis. CONCLUSION: Alport syndrome in pregnancy has the potential for disease acceleration with rapid parallel progression of vasculopathy in the placental and renal circulations. |
Authors:
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Koji Matsuo; Erika L Tudor; Ahmet A Baschat |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 109 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-01 Completed Date: 2007-02-20 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 531-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Science, University of Maryland School of Medicine, Baltimore, Maryland, USA. kmats001@umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Therapeutic Adult Diagnosis, Differential Female Fetal Growth Retardation / diagnosis* Humans Kidney Failure, Acute / complications, diagnosis* Nephritis, Hereditary / complications, diagnosis* Pre-Eclampsia / diagnosis* Pregnancy Pregnancy Trimester, Second Prenatal Diagnosis* |
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