| Alport-like glomerular changes in a patient with nephrotic syndrome: report of a case. | |
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MedLine Citation:
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PMID: 10975309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a 17-year-old Saudi girl who presented with nephrotic syndrome at the age of 7 years. A renal biopsy revealed a mildly proliferative immune complex-mediated glomerulonephritis, which on ultrastructural examination revealed prominent thickening of the capillary basement membranes, along with marked splitting and lamellation of lamina densa resembling those seen in Alport syndrome. These changes were even more pronounced in renal biopsies performed 1 and 3 years later, respectively. Thorough clinical evaluations and follow-up of more than 10 years failed to reveal any evidence of Alport syndrome. Review of the literature revealed four similar cases reported previously. Diffuse and prominent Alport-like glomerular changes may rarely be seen in patients with nephrotic syndrome in the absence of Alport syndrome. Pathogenesis of these changes, however, remains to be understood. |
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Authors:
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M Akhtar; E Al-Sabban |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 14 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-12-04 Completed Date: 2000-12-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 973-5 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. akhtar@kfshrc.edu.sa |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Basement Membrane / ultrastructure Capillaries / pathology Female Humans Kidney Glomerulus / blood supply, pathology* Nephritis, Hereditary / pathology* Nephrotic Syndrome / pathology* |
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