Document Detail

Alphafetoprotein in screening for congenital hypothyroidism.
MedLine Citation:
PMID:  12596967     Owner:  NLM     Status:  MEDLINE    
This study was conducted on 500 full-term neonates and 25 older patients with congenital hypothyroidism (CH), newly or previously diagnosed. Alphafetoprotein (AFP) was elevated in two neonates. In one, persistent elevation of AFP and thyroid stimulating hormone (TSH) with low thyroxine (T4) were found (congenital hypothyroidism). In the other, AFP, TSH and T4 levels normalized (transient hypothyroidism). The mean AFP level in new CH patients was significantly higher than in previously diagnosed patients, and was higher in CH patients than in controls. Significant relationships were found between AFP and T4, AFP and TSH, and AFP and age. AFP is a sensitive indicator of thyroid status and can be used as a screening test for hypothyroidism from the first day of life and in follow-up of CH patients.
R M Shawky; S Abd el-Fattah; M E el-din Azzam; M M Rafik; A Osman
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ     Volume:  7     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:    2001 Jan-Mar
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-03-13     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  171-80     Citation Subset:  IM    
Department of Paediatrics, University of Ain Shams, Cairo, Egypt.
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MeSH Terms
Age Factors
Bilirubin / blood
Case-Control Studies
Child, Preschool
Congenital Hypothyroidism*
Creatinine / blood
Hypothyroidism / blood,  diagnosis*
Infant, Newborn
Neonatal Screening / methods*,  standards
Sensitivity and Specificity
Thyroid Function Tests
Thyrotropin / blood
Thyroxine / blood
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/alpha-Fetoproteins; 60-27-5/Creatinine; 635-65-4/Bilirubin; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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