| Alpha1-antitrypsin single dose adjuvant therapy for acute otitis media. | |
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MedLine Citation:
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PMID: 16815194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Proteases have been shown to play a role in the pathogenesis of otitis media. Inhibition of these proteases can improve treatment outcomes in certain conditions. The goal of this study was to determine if intratympanic administration of a single dose of the protease inhibitor, recombinant alpha 1-antitrypsin (rAAT), can facilitate resolution of acute otitis media (AOM) in the chinchilla. METHODS AND MEASURES: Pneumococcus was injected into both middle ears of 12 chinchillas. After 3 to 4 days, middle ears were cultured, systemic antibiotics were initiated, and rAAT or its vehicle was administered into the middle ears of all animals. Serial tympanic membrane (TM) scoring, tympanometry, and auditory-evoked brain stem response testing were performed. Animals were sacrificed at varying timepoints and temporal bones studied for objective measures of OM. RESULTS: Although not reaching statistical significance, there was a trend to more rapid resolution of AOM in rAAT-treated ears. Tympanometry, auditory thresholds, and quantitative histologic parameters did not differ between rAAT and vehicle treated ears. CONCLUSIONS: A single dose of intratympanic rAAT likely does not facilitate the resolution of antibiotic-treated pneumococcal AOM in the chinchilla model. Serial administration of this protease inhibitor may be necessary to see a significant treatment effect. |
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Authors:
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Patrick J Antonelli; Gregory S Schultz; David J Sundin; Philip A Pemberton; Philip J Barr |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 135 ISSN: 0194-5998 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-03 Completed Date: 2006-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 111-5 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA. antonpj@ent.ufl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Auditory Threshold Chinchilla Disease Models, Animal Dose-Response Relationship, Drug Female Male Otitis Media / drug therapy*, microbiology, physiopathology Pneumococcal Infections / drug therapy, microbiology Streptococcus pneumoniae / pathogenicity Treatment Outcome Trypsin Inhibitors / administration & dosage, therapeutic use* alpha 1-Antitrypsin / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Trypsin Inhibitors; 0/alpha 1-Antitrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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