Document Detail

Alpha1-antitrypsin phenotypes and lung function in a moderately polluted northern Ontario community.
MedLine Citation:
PMID:  306869     Owner:  NLM     Status:  MEDLINE    
To determine whether persons with intermediate value alpha1-antitrypsin phenotypes living in a polluted environment manifest significant abnormalities in lung function, a study was undertaken of an age-, sex- and smoking-stratified sample of 391 persons from the town of Fort Frances, Ont., which has elevated values of total dustfall, suspended particulates and hydrogen sulfide. Indices of pulmonary function were derived from the maximum expiratory flow and the single breath expiratory flow and the single breath expiratory nitrogen washout curves. The percentage frequency of the M, MS and MZ pheontypes was 91.7, 7.3 and 0.8, respectively. There was no significant difference between the M and MS groups as indicated by the nitrogen washout curve and maximum expiratory flow curve. There was no significant difference between the three MZ subjects and the M group. In both M and MS groups smokers displayed evidence of airflow obstruction when compared with nonsmokers. It would appear that, when compared with M subjects, persons with the MS phenotype living in a moderately polluted area show no changes in indicators of pulmonary function, including tests of early airway disease, that cannot be attributed to their smoking habit.
D N Ostrow; J Manfreda; T Dorman; R M Cherniack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  118     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  669-72     Citation Subset:  AIM; IM    
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MeSH Terms
Air Pollution*
Lung / physiology*
Middle Aged
Respiratory Function Tests
alpha 1-Antitrypsin / genetics*
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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