| Alpha(1)-antichymotrypsin gene polymorphism in patients with stroke. | |
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MedLine Citation:
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PMID: 10978037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: A role for proteolytic enzymes has been suggested in the pathogenesis of stroke. In a search for new genetic factors, we investigated the gene polymorphism of the serine protease inhibitor alpha(1)-antichymotrypsin (ACT) in patients with stroke. METHODS: Two hundred twenty patients with acute ischemic stroke (n=182) and primary intracerebral hemorrhage (n=38) and 70 control subjects without clinical cerebrovascular disease were genotyped for the ACT polymorphism. RESULTS: The ACT-TT genotype was more frequent in patients with primary intracerebral hemorrhage than in patients with ischemic stroke (31.6% versus 16.4%, P:<0.05) or in control subjects (21.4%, P:=0.1). After adjusting for age, gender, and vascular risk factors, the ACT-TT genotype was associated with primary intracerebral hemorrhage, with an OR of 2.3 (95% CI 1.0 to 5. 2) compared with ischemic stroke and an OR of 1.8 (95% CI 0.85 to 9. 65) compared with controls. CONCLUSIONS: Pending confirmation in a larger study, our results suggest that the ACT-TT genotype might be a risk factor for primary cerebral hemorrhage. |
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Authors:
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N Vila; V Obach; M Revilla; R Oliva; A Chamorro |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 31 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-17 Completed Date: 2000-10-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2103-5 Citation Subset: IM |
Affiliation:
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Neurology Service, Hospital Clinic, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Cerebral Hemorrhage / blood, diagnosis, genetics* Female Genotype Humans Male Middle Aged Odds Ratio Polymorphism, Genetic Serine Proteinase Inhibitors / genetics* Stroke / blood, diagnosis, genetics* alpha 1-Antichymotrypsin / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Serine Proteinase Inhibitors; 0/alpha 1-Antichymotrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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