Document Detail

Alpha(1)-antichymotrypsin gene polymorphism in patients with stroke.
MedLine Citation:
PMID:  10978037     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: A role for proteolytic enzymes has been suggested in the pathogenesis of stroke. In a search for new genetic factors, we investigated the gene polymorphism of the serine protease inhibitor alpha(1)-antichymotrypsin (ACT) in patients with stroke. METHODS: Two hundred twenty patients with acute ischemic stroke (n=182) and primary intracerebral hemorrhage (n=38) and 70 control subjects without clinical cerebrovascular disease were genotyped for the ACT polymorphism. RESULTS: The ACT-TT genotype was more frequent in patients with primary intracerebral hemorrhage than in patients with ischemic stroke (31.6% versus 16.4%, P:<0.05) or in control subjects (21.4%, P:=0.1). After adjusting for age, gender, and vascular risk factors, the ACT-TT genotype was associated with primary intracerebral hemorrhage, with an OR of 2.3 (95% CI 1.0 to 5. 2) compared with ischemic stroke and an OR of 1.8 (95% CI 0.85 to 9. 65) compared with controls. CONCLUSIONS: Pending confirmation in a larger study, our results suggest that the ACT-TT genotype might be a risk factor for primary cerebral hemorrhage.
N Vila; V Obach; M Revilla; R Oliva; A Chamorro
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  31     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-17     Completed Date:  2000-10-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2103-5     Citation Subset:  IM    
Neurology Service, Hospital Clinic, Barcelona, Spain.
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MeSH Terms
Acute Disease
Aged, 80 and over
Cerebral Hemorrhage / blood,  diagnosis,  genetics*
Middle Aged
Odds Ratio
Polymorphism, Genetic
Serine Proteinase Inhibitors / genetics*
Stroke / blood,  diagnosis,  genetics*
alpha 1-Antichymotrypsin / genetics*
Reg. No./Substance:
0/Serine Proteinase Inhibitors; 0/alpha 1-Antichymotrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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