| Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group. | |
| | |
MedLine Citation:
|
PMID: 9633757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels. |
| | |
Authors:
|
G T Vatassery; S Fahn; M A Kuskowski |
Related Documents
:
|
6291907 - Metabolism of vitamin d3 in nephrectomized pigs given pharmacological amounts of vitami... 19151237 - Functional vitamin b12 deficiency. 15261987 - The effects of tobacco smoke on plasma alpha- and gamma-tocopherol levels in passive an... 6896257 - Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalcife... 8369807 - Reciprocal changes in complement activity and immune-complex levels during plasma infus... 9988207 - Anaphylaxis to omeprazole. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neurology Volume: 50 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1998 Jun |
Date Detail:
|
Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1900-2 Citation Subset: AIM; IM |
Affiliation:
|
GRECC, VA Medical Center, Department of Psychiatry, University of Minnesota, Minneapolis 55417, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antioxidants
/
therapeutic use Antiparkinson Agents / therapeutic use Dose-Response Relationship, Drug Double-Blind Method Humans Parkinson Disease / drug therapy* Selegiline / therapeutic use Vitamin E / administration & dosage*, cerebrospinal fluid*, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
|
AG 10528/AG/NIA NIH HHS; NS24778/NS/NINDS NIH HHS; RR00645/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Antiparkinson Agents; 1406-18-4/Vitamin E; 14611-51-9/Selegiline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Visual activation patterns in patients with optic neuritis: an fMRI pilot study.
Next Document: Unilateral neglect: a common but heterogeneous syndrome.