Document Detail

Alpha-tocopherol controls cell proliferation in the adult rat dentate gyrus.
MedLine Citation:
PMID:  11323119     Owner:  NLM     Status:  MEDLINE    
The effect of alpha-tocopherol on cell proliferation and proliferated cell survival was investigated in the dentate gyrus of adult rats. Adult rats were supplemented with alpha-tocopherol, injected with 5-bromo-2'-deoxyuridine (BrdU), that is incorporated into DNA during the S-phase, and killed at different time after BrdU injection. The number of newborn cells decreased after alpha-tocopherol supplementation, confirming the hypothesis that alpha-tocopherol is able to depress cell proliferation in vivo. Most newborn cells die within few days; more newborn cells survive in alpha-tocopherol-treated rats, suggesting the hypothesis that alpha-tocopherol decreases cell death.
R Cuppini; S Ciaroni; T Cecchini; P Ambrogini; P Ferri; P Del Grande; S Papa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  303     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-08-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  198-200     Citation Subset:  IM    
Institute of Physiological Sciences, Università degli Studi di Urbino loc. Crocicchia I-61029 (PS), Urbino, Italy.
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MeSH Terms
Age Factors
Bromodeoxyuridine / pharmacokinetics
Cell Count
Cell Death / drug effects,  physiology
Cell Division / drug effects*,  physiology
Dentate Gyrus / cytology,  drug effects*,  growth & development
Neurons / cytology,  drug effects*,  metabolism
Rats, Sprague-Dawley
Stem Cells / cytology,  drug effects,  metabolism
Vitamin E / pharmacology*
Vitamin E Deficiency / metabolism,  pathology,  physiopathology
Reg. No./Substance:
1406-18-4/Vitamin E; 59-14-3/Bromodeoxyuridine

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