Document Detail


Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour.
MedLine Citation:
PMID:  18295208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Up to 40% of Parkinson's disease patients suffer from anxiety, but little is known about the mechanisms involved. We used the elevated plus maze and open field test to evaluate groups of young adult mice expressing different levels of alpha-synuclein, including mice transgenic for human alpha-synuclein with the A53T mutation. Compared to alpha-synuclein knock-out mice and wild-type controls, alpha-synuclein A53T transgenic mice exhibited reduced anxiety-like behaviour by spending markedly greater amounts of time on the maze open arms and by a higher proportion of entries to the open arms. In the open field, transgenic mice showed a trend towards reduced locomotor habituation and increased thigmotaxis. These results indicate a possible role for alpha-synuclein in anxiety-like behaviours.
Authors:
Sonia George; Maarten van den Buuse; Su San Mok; Colin L Masters; Qiao-Xin Li; Janetta G Culvenor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-04
Journal Detail:
Title:  Experimental neurology     Volume:  210     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  788-92     Citation Subset:  IM    
Affiliation:
Department of Pathology, The Centre for Neuroscience, The University of Melbourne, Parkville, Victoria, 3010, Australia.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anxiety / genetics*,  physiopathology*
Behavior, Animal / physiology
Exploratory Behavior / physiology
Humans
Maze Learning / physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Motor Activity / genetics
Mutation / physiology*
alpha-Synuclein / genetics*
Chemical
Reg. No./Substance:
0/alpha-Synuclein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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