| Alpha-particle irradiation of haemopoietic tissue in pre- and postnatal mice. 1: Distribution of plutonium-239 after mid-term contamination. | |
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MedLine Citation:
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PMID: 1671696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant mice (at 13 days gestation) and age-matched controls were injected with 30 kBq 239Pu/kg and the distribution of plutonium in maternal and foetal tissues measured. Approximately 2% of the activity injected into the mother reached each foetus in 24 h, 95% of which was contained in membranes and placenta. The concentration of plutonium in foetal liver was 3 times the average foetal body concentration; both liver and body concentrations in the foetus increased by the end of gestation. Each pup accumulated only 0.01% extra injected activity after 9 days lactation and, as the resulting concentrations in the neonatal skeleton were low, we conclude that the greatest haemopoietic risk to the offspring from mid-term contamination in utero is in the foetal liver (which received an average dose of 10-14 mGy between the time of mid-term contamination and birth). By the end of gestation about one-quarter of the original activity was transferred to foetal tissues from the maternal liver and skeleton. No significant changes in maternal distribution were detected as a result of lactation. The results of this study are discussed, along with a compilation of previously published data. |
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Authors:
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T M Mason; E R Humphreys; B I Lord |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation biology Volume: 59 ISSN: 0955-3002 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-25 Completed Date: 1991-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 467-78 Citation Subset: IM; S |
Affiliation:
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Cancer Research Campaign Department of Experimental Haematology, Peterson Institute for Cancer Research, Withington, Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / metabolism* Female Injections, Intravenous Lactation / metabolism* Maternal-Fetal Exchange* Mice Mice, Inbred C57BL Plutonium / administration & dosage, pharmacokinetics* Pregnancy Pregnancy, Animal / metabolism* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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7440-07-5/Plutonium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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