Document Detail

Alpha-neo-endorphin coexists with dynorphin-A(1-8) within intramurally lying perikarya of rat duodenum.
MedLine Citation:
PMID:  2877446     Owner:  NLM     Status:  MEDLINE    
By the use of the immunofluorescent microscopic staining technique, adjacent serial sections through the rat duodenum were alternately stained with specific antisera directed to the opioid peptides alpha-neo-endorphin and dynorphin-A(1-8). alpha-Neo-endorphin immunoreactivity has been revealed exclusively within perikarya lying intramurally in the longitudinal muscle layer. These alpha-neo-endorphin and dynorphin-A(1-8) immunoreactive perikarya were large in diameter, round in shape, contained a large and round nucleus, and were recognized only occasionally there. alpha-Neo-endorphin immunoreactivity was coexistent with dynorphin-A(1-8)-positive material within these perikarya. Since no alpha-neo-endorphin material was detected within duodenal nerve fibres and terminals, it might be concluded that this peptide is further enzymatically cleaved to the opioid pentapeptide Leu-enkephalin during its axonal transport from intramural perikarya to nerve terminals and during its storage there.
H J Wolter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  7     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1986-12-04     Completed Date:  1986-12-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-92     Citation Subset:  IM    
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MeSH Terms
Duodenum / cytology*
Dynorphins / analysis*
Endorphins / analysis*
Fluorescent Antibody Technique
Immune Sera
Peptide Fragments / analysis*
Protein Precursors / analysis*
Rats, Inbred Strains
Reg. No./Substance:
0/Endorphins; 0/Immune Sera; 0/Peptide Fragments; 0/Protein Precursors; 69671-17-6/alpha-neoendorphin; 74913-18-1/Dynorphins; 75790-53-3/dynorphin (1-8)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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