| Alpha-melanocyte-stimulating hormone attenuates behavioral effects of corticotropin-releasing factor in isolated guinea pig pups. | |
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MedLine Citation:
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PMID: 19492314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During a 3-hr period of social isolation in a novel environment, guinea pig pups exhibit an initial active phase of behavioral responsiveness, characterized primarily by vocalizing, which is then followed by a stage of passive responsiveness in which pups display a distinctive crouch, eye-closing, and extensive piloerection. Prior treatment of pups with alpha-melanocyte-stimulating hormone (alpha-MSH) reduces each of the passive behaviors. The onset of passive responding during separation can be accelerated with peripheral injection of corticotropin-releasing factor (CRF). To examine whether CRF produces its effects through a mechanism similar to that of prolonged separation, we examined the effect of administering alpha-MSH to pups injected with CRF. As expected, CRF markedly enhanced passive responding during a 60-min period of separation. alpha-MSH delivered by either intracerebroventricular infusion or intraperitoneal injection significantly reduced each of the passive behavioral responses without significantly affecting active behavior. These findings, together with previous results indicating that it is the anti-inflammatory property of alpha-MSH that is responsible for its behavioral effects during prolonged separation, suggest that peripheral CRF speeds the induction of passive responding through a mechanism involving enhanced proinflammatory activity. |
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Authors:
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Patricia A Schiml-Webb; Emily Miller; Terrence Deak; Michael B Hennessy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Developmental psychobiology Volume: 51 ISSN: 1098-2302 ISO Abbreviation: Dev Psychobiol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: United States |
Other Details:
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Languages: eng Pagination: 399-407 Citation Subset: IM |
Affiliation:
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Department of Psychology, Wright State University, 335 Fawcett Hall, Dayton, OH 45435, USA. patricia.schiml@wright.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Atropine / administration & dosage Behavior, Animal / drug effects* Brain / surgery Corticotropin-Releasing Hormone / drug effects* Guinea Pigs Illness Behavior / drug effects Injections, Intramuscular Social Isolation* Stereotaxic Techniques Vocalization, Animal alpha-MSH / administration & dosage, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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MH 068228/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-55-8/Atropine; 581-05-5/alpha-MSH; 9015-71-8/Corticotropin-Releasing Hormone |
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