Document Detail


Alpha-mannosidosis. Report of a case with morphologic, cytologic and immunohistochemical considerations.
MedLine Citation:
PMID:  8191839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the histopathologic features of the knee bone and synovium and the cytologic features of the synovial fluid from a patient with alpha-mannosidosis. The synovium showed marked papillary hyperplasia with infiltration of foamy histiocytes containing periodic acid-Schiff-positive, diastase-resistant material. Severe degenerative changes were seen in the knee bone. The synovial fluid showed increased numbers of macrophages containing periodic acid-Schiff-positive, diastase-resistant material. The differential diagnostic considerations in the synovial fluid are also discussed.
Authors:
B Krishnan; D R Mody; I Ramzy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  38     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1994-06-22     Completed Date:  1994-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030.
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MeSH Terms
Descriptor/Qualifier:
Adult
Erythrocytes / pathology
Humans
Hyperplasia
Knee Joint / pathology*,  surgery
Macrophages / pathology
Male
Mannosidases / deficiency*
Synovial Fluid / cytology*
Synovial Membrane / pathology*,  ultrastructure
Vacuoles / pathology,  ultrastructure
alpha-Mannosidase
alpha-Mannosidosis / pathology*
Chemical
Reg. No./Substance:
EC 3.2.1.-/Mannosidases; EC 3.2.1.24/alpha-Mannosidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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