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Alpha-lipoic Acid and diabetic neuropathy.
MedLine Citation:
PMID:  20043035     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Diabetic neuropathy presents a major public health problem. It is defined by the symptoms and signs of peripheral nerve dysfunction in diabetic patients, in whom other causes of neuropathy have been excluded. Pathogenetic mechanisms that have been implicated in diabetic neuropathy are: a) increased flux through the polyol pathway, leading to accumulation of sorbitol, a reduction in myo-inositol, and an associated reduced Na+-K+-ATPase activity, and b) endoneurial microvascular damage and hypoxia due to nitric oxide inactivation by increased oxygen free radical activity. Alpha-lipoic acid seems to delay or reverse peripheral diabetic neuropathy through its multiple antioxidant properties. Treatment with alpha-lipoic acid increases reduced glutathione, an important endogenous antioxidant. In clinical trials, 600 mg alpha-lipoic acid has been shown to improve neuropathic deficits. This review focuses on the relationship of alpha-lipoic acid and auto-oxidative glycosylation. It discusses the impact of alpha-lipoic acid on hyperglycemia-induced oxidative stress, and examines the role of alpha-lipoic acid in preventing glycation process and nerve hypoxia.
Authors:
Natalia Vallianou; Angelos Evangelopoulos; Pavlos Koutalas
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Publication Detail:
Type:  Journal Article     Date:  2009-12-30
Journal Detail:
Title:  The review of diabetic studies : RDS     Volume:  6     ISSN:  1614-0575     ISO Abbreviation:  Rev Diabet Stud     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101227575     Medline TA:  Rev Diabet Stud     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  230-6     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Polykliniki General Hospital, 3 Pireos Str., 10552 Athens, Greece.
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