Document Detail

Alpha-linolenic acid, long-chain n-3 fatty acids, and neonatal brain development.
MedLine Citation:
PMID:  1686983     Owner:  NLM     Status:  MEDLINE    
There appear to be mechanisms that enable the developing brain to regulate its concentration of 22:6n-3 in response to both dietary deficiencies and excesses. This appears to be true whether the n-3 fatty acids are supplied as 18:3n-3 or the long-chain derivatives, suggesting that the presence of 22:6n-3 during development may be of functional consequence to the operation of the nervous system. Although there is experimental support for specific effects of n-3 fatty acids on retinal function, further studies with better methodological controls are needed before effects on cognitive function in rodents can be considered unequivocal.
P E Wainwright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  7     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1991 Nov-Dec
Date Detail:
Created Date:  1992-04-30     Completed Date:  1992-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  443-6     Citation Subset:  IM    
Department of Health Studies, University of Waterloo, Ontario, Canada.
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MeSH Terms
Animals, Newborn / growth & development*
Brain / growth & development*,  metabolism
Dietary Fats, Unsaturated / pharmacology
Fatty Acids, Unsaturated / physiology*,  therapeutic use
Linolenic Acids / physiology*
alpha-Linolenic Acid
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 0/Linolenic Acids; 463-40-1/alpha-Linolenic Acid

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