Document Detail


Alpha-linolenic acid in rapeseed oil partly compensates for the effect of fish restriction on plasma long chain n-3 fatty acids.
MedLine Citation:
PMID:  8730609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the ability of alpha-linolenic acid (ALA) in low erucic acid rapeseed oil (RO) to compensate for the effects of a restriction in fish intake on plasma fatty acid composition. DESIGN AND SUBJECTS: Two times 6 weeks' randomized dietary intervention was used with blind crossover design in 40 healthy unconfined women and men (age 20-46y). INTERVENTIONS: Subjects were assigned to two fish restricted diets, namely RO diet and Trisun-sunflower oil (TSO) diet, with similar proportions of saturated : monounsaturated : polyunsaturated fatty acids (11.5:17.5:8.5% of total energy, En%), but differing in their ALA content (2.2 and 0.3 En%) and n-6 : n-3-ratio (3 : 1 and 23 : 1, respectively). The fatty acid compositions of plasma triglycerides (TG), cholesterol esters (CE), and phospholipids (PL) were analyzed by gas chromatography. Dietary intake was evaluated based on 3- to 7-day food records. RESULTS: The proportion of TG and CE ALA decreased on the TSO diet (from 1.6% to 0.9% and from 0.9% to 0.4%, respectively, P < 0.001) and increased on the RO diet (from 1.7% to 3.4% and from 0.9% to 1.3%, respectively, P < 0.001) compared to the baseline level. The proportion of eicosapentaenoic acid (EPA) in all three plasma fractions decreased on the TSO diet but not on the RO diet. The proportions of docosa-hexaenoic acid (DHA) decreased on both experimental diets and there was no difference in CE DHA between the diets. PL docosa-pentaenoic acid (DPA) and PL DHA remained at a higher level on the RO diet compared to the TSO diet (P < 0.001 and P < 0.05, respectively). CONCLUSIONS: ALA is metabolized to EPA in humans to a significant extent. The degree to which rapeseed oil (ca 50g/day) affects the proportion of EPA resembled the effect of a weekly portion (50-100g) of fatty fish depending on the fat content of the fish.
Authors:
L M Valsta; I Salminen; A Aro; M Mutanen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  50     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-26     Completed Date:  1996-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  229-35     Citation Subset:  IM    
Affiliation:
Department of Nutrition, National Public Health Institute, Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brassica / chemistry*
Cholesterol Esters / blood
Cross-Over Studies
Dietary Fats, Unsaturated / administration & dosage,  pharmacology*
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Fatty Acids / blood
Fatty Acids, Monounsaturated / blood
Fatty Acids, Omega-3 / analysis,  blood*
Fatty Acids, Unsaturated / blood
Female
Fish Products* / analysis,  standards
Helianthus
Humans
Male
Middle Aged
Phospholipids / blood
Plant Oils / administration & dosage
Triglycerides / blood
alpha-Linolenic Acid / analysis,  pharmacology*
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Plant Oils; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 8001-21-6/sunflower seed oil

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