| THE ALPHA LINOLENIC ACID CONTENT OF FLAXSEED CAN PREVENT THE ATHEROGENIC EFFECTS OF DIETARY TRANS FAT. | |
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MedLine Citation:
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PMID: 21963840 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective - Dietary intake of industrially hydrogenated trans fatty acids (TFA) has been associated with coronary heart disease. Dietary flaxseed can inhibit atherosclerosis induced by dietary cholesterol. The aim of this study was to determine if supplementing the diet with flaxseed could protect against atherosclerosis induced by a diet enriched in TFA. Methods and Results - Low-density lipoprotein receptor deficient (LDLr(-/-)) mice were fed one of 14 experimental diets for 14 weeks containing one of two fat sources (regular (pork/soy) or trans fat) at two concentrations (4 or 8%) and supplemented with or without dietary cholesterol (2%), whole ground flaxseed or one of the components of flaxseed (α-linolenic acid (ALA), defatted fiber or lignan). Adding flaxseed to the diet partially mitigated the rise in circulating cholesterol levels induced by the cholesterol-enriched diet. Atherosclerosis was stimulated by TFA and/or cholesterol. Including milled flaxseed to an atherogenic diet significantly reduced atherosclerosis as compared to the groups that consumed cholesterol and/or TFA. ALA was the only component within flaxseed that could inhibit the atherogenic action of cholesterol and/or TFA on its own. Conclusion - Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA. |
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Authors:
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Chantal M C Bassett; Richelle S McCullough; Andrea L Edel; Amanda Patenaude; Renee K La Vallee; Grant N Pierce |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-30 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1St Boniface Hospital Research Centre. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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