Document Detail

Alpha-ketoglutarate for myocardial protection in heart surgery.
MedLine Citation:
PMID:  7776775     Owner:  NLM     Status:  MEDLINE    
A low myocardial content of alpha-ketoglutarate during heart surgery might aggravate ischaemic injury. 24 men undergoing coronary surgery participated in a randomised controlled study. 28 g alpha-ketoglutarate was added to blood cardioplegia for intermittent antegrade intracoronary perfusion in 13 cases. alpha-ketoglutarate reduced the appearance in blood of the ischaemic markers creatine kinase MB and troponin T (at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T). These findings signify attenuated ischaemic injury, possibly secondary to enhanced myocardial oxidative capacity.
U Kjellman; K Björk; R Ekroth; H Karlsson; R Jagenburg; F Nilsson; G Svensson; J Wernerman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lancet     Volume:  345     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-07     Completed Date:  1995-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  552-3     Citation Subset:  AIM; IM    
Department of Thoracic and Cardiovascular Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Cardioplegic Solutions / administration & dosage*
Cardiopulmonary Bypass
Coronary Artery Bypass* / adverse effects
Coronary Disease / surgery
Creatine Kinase / blood
Ketoglutaric Acids / administration & dosage*
Lactates / metabolism
Lactic Acid
Myocardial Ischemia / prevention & control
Myocardium / metabolism
Oxygen / metabolism
Troponin / blood
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Isoenzymes; 0/Ketoglutaric Acids; 0/Lactates; 0/Troponin; 328-50-7/alpha-ketoglutaric acid; 50-21-5/Lactic Acid; 7782-44-7/Oxygen; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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