Document Detail


Alpha-ketoglutarate for myocardial protection in heart surgery.
MedLine Citation:
PMID:  7776775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A low myocardial content of alpha-ketoglutarate during heart surgery might aggravate ischaemic injury. 24 men undergoing coronary surgery participated in a randomised controlled study. 28 g alpha-ketoglutarate was added to blood cardioplegia for intermittent antegrade intracoronary perfusion in 13 cases. alpha-ketoglutarate reduced the appearance in blood of the ischaemic markers creatine kinase MB and troponin T (at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T). These findings signify attenuated ischaemic injury, possibly secondary to enhanced myocardial oxidative capacity.
Authors:
U Kjellman; K Björk; R Ekroth; H Karlsson; R Jagenburg; F Nilsson; G Svensson; J Wernerman
Related Documents :
21223485 - High-output heart failure secondary to arteriovenous fistula.
21236505 - Defining high-risk patients with st-segment elevation acute myocardial infarction under...
18687565 - The etiology and prognostic significance of cardiac troponin i elevation in unselected ...
16169315 - Effects of tirofiban plus clopidogrel versus clopidogrel plus provisional abciximab on ...
20881485 - Recent advances in cardiac rehabilitation.
21487455 - Complete recovery of ischemic cardiomyopathy from thrombotic thrombocytopenic purpura.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lancet     Volume:  345     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-07     Completed Date:  1995-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  552-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cardioplegic Solutions / administration & dosage*
Cardiopulmonary Bypass
Coronary Artery Bypass* / adverse effects
Coronary Disease / surgery
Creatine Kinase / blood
Humans
Isoenzymes
Ketoglutaric Acids / administration & dosage*
Lactates / metabolism
Lactic Acid
Male
Myocardial Ischemia / prevention & control
Myocardium / metabolism
Oxygen / metabolism
Troponin / blood
Chemical
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Isoenzymes; 0/Ketoglutaric Acids; 0/Lactates; 0/Troponin; 328-50-7/alpha-ketoglutaric acid; 50-21-5/Lactic Acid; 7782-44-7/Oxygen; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Primary prevention of cryptococcal meningitis by fluconazole in HIV-infected patients.
Next Document:  Cardiac chamber-specific beta-adrenoceptor regulation and sympathetic innervation.