Document Detail

Alpha interferon treatment in atopic dermatitis.
MedLine Citation:
PMID:  8103259     Owner:  NLM     Status:  MEDLINE    
Eight patients suffering from atopic dermatitis were treated with interferon alpha 2b. They received low or intermediate doses (9-15 x 10(6) U/week) for a short period of time (4-8 weeks), with a moderate improvement of skin lesions in 4 of them and no change or an exacerbation of the disease in the other 4. Among the 4 patients who slightly improved at 4 weeks, 3 did not show any beneficial effect of interferon after 8 weeks. Serum IgE levels, which were increased in all patients before treatment, were not reduced under interferon therapy. This study shows that intermediate doses of interferon alpha 2b are not effective in the short-term treatment of atopic dermatitis.
D Jullien; J F Nicolas; A Frappaz; J Thivolet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  73     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-09-28     Completed Date:  1993-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  130-2     Citation Subset:  IM    
INSERM U.346, Hôpital E. Herriot, Lyon, France.
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MeSH Terms
Chronic Disease
Dermatitis, Atopic / blood,  therapy*
Immunoglobulin E / blood
Interferon Alfa-2b / therapeutic use*
Time Factors
Treatment Outcome
Reg. No./Substance:
37341-29-0/Immunoglobulin E; 99210-65-8/Interferon Alfa-2b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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