Document Detail


Alpha-interferon prevents liver collagen deposition and damage induced by prolonged bile duct obstruction in the rat.
MedLine Citation:
PMID:  8773918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Interferons have been used to treat chronic viral hepatitis, due to their antiviral properties. However, interferons are now recognized also to inhibit collagen production. Since fibrosis has been associated with liver damage and dysfunction, the effects of interferon-alpha 2 b on biliary obstruction-induced fibrosis were investigated. METHODS: Extrahepatic cholestasis was induced in male Wistar rats (around 200g) by double ligation and division of the common bile duct. Control rats were sham operated. Interferon-alpha 2b (IFN-alpha; 100,000 IU/rat) was administered subcutaneously, daily after surgery. The animals were killed after 4 weeks of bile duct ligation or sham operation. Liver damage and cholestasis was analyzed by histological, ultrastructural and biochemical techniques. RESULTS: Biliary obstruction produced dilation of the bile canaliculi, disorganization of mitochondria and an increase in vacuolization. Bile duct ligation led to an important accumulation of collagen, determined, both histologically and as the hydroxyproline content of the liver. Bilirubin and serum enzyme activities (determined as markers of cholestasis) increased several-fold after bile duct ligation. Administration of IFN-alpha to bile duct ligated rats resulted in significant preservation of ultrastructure, histology, inhibition of collagen accumulation and in a partial improvement of serum markers of cholestasis. CONCLUSIONS: It is concluded that interferons possess interesting beneficial effects on the liver not related to its antiviral properties but probably associated with its antifibrogenic properties.
Authors:
P Muriel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  24     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-22     Completed Date:  1996-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  614-21     Citation Subset:  IM    
Affiliation:
Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del I.P.N. México, D.F. México.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Cholestasis, Extrahepatic / drug therapy*,  metabolism
Collagen / metabolism*
Interferon Alfa-2b / therapeutic use*
Lipid Peroxidation / drug effects
Liver / drug effects*,  metabolism,  pathology
Liver Glycogen / metabolism
Male
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Liver Glycogen; 9007-34-5/Collagen; 99210-65-8/Interferon Alfa-2b

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