| Alpha interferon has no effect on lidocaine metabolism in the rat. | |
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MedLine Citation:
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PMID: 8001595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interferons (IFN) inhibit activity of many isoenzymes of the hepatic microsomal cytochrome P-450 system. This inhibition is species specific. Lidocaine is metabolized by cytochrome P-450 III A 4. We investigated in the rat the effect of rat alpha-IFN on lidocaine elimination and on its extraction by the isolated perfused rat liver. To determine elimination, the femoral artery and vein were cannulated. 24 h later, the conscious rat was given lidocaine through the venous catheter and blood was drawn from the arterial catheter for lidocaine determination every 3 min for 20 min. 7 rats were pre-treated with intramuscular rat alpha-IFN 7.5 x 10(5) U, 24 h prior to the experiment and another 4 rats were given saline i.m. The lidocaine elimination rate constant was unchanged, 0.065 min-1 and 0.063 min-1 for the control and IFN groups, respectively. To investigate lidocaine extraction, the isolated perfused rat liver was used. Perfusate samples from the portal and hepatic veins were drawn at 2 min intervals for 20 min, and lidocaine extraction determined. Extraction was determined in two groups of 6 rats each. The first group served as control and these rats were injected with saline only, while in the second group, the rats were pre-treated with rat alpha-IFN 7.5 x 10(5) U. Lidocaine extraction by the isolated perfused rat liver remained unchanged, 97.0 +/- 0.7% and 94.0 +/- 2.4% in the control and IFN treated groups, respectively. It is concluded that the rat alpha-IFN affects neither the elimination nor the extraction of lidocaine. |
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Authors:
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E Melzer; E Bardan; I Ronen; Z Krepel; S Bar Meir |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of drug metabolism and pharmacokinetics Volume: 19 ISSN: 0378-7966 ISO Abbreviation: Eur J Drug Metab Pharmacokinet Publication Date: 1994 Apr-Jun |
Date Detail:
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Created Date: 1995-01-24 Completed Date: 1995-01-24 Revised Date: 2011-02-02 |
Medline Journal Info:
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Nlm Unique ID: 7608491 Medline TA: Eur J Drug Metab Pharmacokinet Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 151-5 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Drug Interactions Half-Life Interferon-alpha / pharmacology* Lidocaine / pharmacokinetics* Liver / drug effects, metabolism Organ Size Rats |
| Chemical | |
Reg. No./Substance:
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0/Interferon-alpha; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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