Document Detail


Alpha-hemoglobin regulates sympathoadrenal cell metabolism to maintain catecholaminergic phenotype.
MedLine Citation:
PMID:  22060312     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Discovery of hemoglobin A expression outside of the erythroid cell lineage suggests that oxygen transport is the main but not the unique function of adult hemoglobin chains in mammalians. The contribution of hemoglobin A to antioxidant defenses has been proposed in the territories where it is expressed. Catecholaminergic cells relay on an active oxidative metabolism to accomplish their biological function but are exposed to strong oxidative stress due to metabolism of catecholaminergic transmitters. We show here that peripheral catecholaminegic cells express the alpha and not the beta hemoglobin A chains and that alpha-hemoglobin expression could modulate the antioxidant capabilities of these cells. We also show that alpha hemoglobin overexpression in PC12 cells leads to a selective increase of tyrosine hydroxylase synthesis and activity. This is achieved by means of a reorganization of antioxidant defenses, decreasing cytoplasmic glutathione peroxidase and superoxide dismutase and increasing mitochondrial peroxidase. Moreover, alpha hemoglobin induces a decrease in lipogenesis and increase in lipid degradation, situations that help saving NAD(P)H and favor supply of acetyl-CoA to the Krebs cycle and production of cell's reducing equivalents. All these data point to a role of alpha hemoglobin as a regulator of catecholaminergic cells metabolism required for phenotype acquisition and maintenance.
Authors:
Maria Teresa Marcos-Almaraz; Jose Antonio Rodriguez-Gomez; Jose Lopez-Barneo; Alberto Pascual
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-8
Journal Detail:
Title:  The Biochemical journal     Volume:  -     ISSN:  1470-8728     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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