Document Detail


Alpha-galactosidase a activity levels in Turkish male hemodialysis patients.
MedLine Citation:
PMID:  23190516     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Fabry disease is an X-linked lysosomal storage disorder due to deficient activity of alpha-galactosidase A (α-Gal A) leading to renal insufficiency in males. The aim of present study was to investigate the level of α-Gal A activity and to determine the prevalence of Fabry disease in a Turkish male hemodialysis population. The activity of plasma α-Gal A was measured in a group of 808 male hemodialysis patients using fluorimetric methods. Patients with low α-Gal A activity were evaluated clinically and genetic testing was carried out. A correlation with creatinine, uric acid, urea, white blood cell (WBC), and high sensitivity (hs)CRP and α-Gal A activity was also investigated. Plasma α-Gal A activity among this male population undergoing hemodialysis was 7.88 ± 5.18 µM/hour/L (0.40-55.72), significantly lower when compared to controls. No influence of creatinine, uric acid, WBC, or hsCRP on measured α-Gal A activity was reported. Two new Fabry disease patients were identified. Both were previously diagnosed with diabetes mellitus type 2. These findings provide, for the first time, data regarding the prevalence of α-Gal A deficiency (0.24%) in Turkish males receiving hemodialysis.
Authors:
Sema Kalkan Uçar; Eser Sozmen; Soner Duman; Ali Başçi; Mahmut Coker
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Publication Detail:
Type:  Journal Article     Date:  2012-08-13
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  16     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  560-5     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.
Affiliation:
Departments of Pediatric Metabolic Disease Biochemistry Nephrology, University Medical Faculty, Izmir, Turkey.
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